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呂昆翰

姓名

呂昆翰

職稱

副教授

學歷

國立清華大學生醫工程與環境科學系博士

國立東華大學資訊工程學系碩士

專長

核醫影像處理分析;核醫物理與儀器;臨床核醫技術

E-mail

khlue@ems.tcust.edu.tw

聯絡電話

(03)8572158 ext. 2702

專業執照

醫事放射師;輻射防護師

教學科目

核醫影像物理、核醫器材學、核醫技術學、醫學影像處理、醫學影像程式概論、醫放專業術語、數位影像處理程式寫作、研究計畫論文寫作

 
期刊論文 (*通訊作者):
01. Yu-Hung Chen, Kuo-Yi Kan, Shu-Hsin Liu , Hsin-Hon Lin, and Kun-Han Lue*. Impact of respiratory motion on 18F-FDG PET radiomics stability: Clinical evaluation with a digital PET scanner. J Appl Clin Med Phys . 2023;24:e14200 (SCIE).
02. Kun-Han Lue, Yu-Hung Chen, Sung-Chao Chu, Bee-Song Chang, Chih-Bin Lin, Yen-Chang Chen, Hsin-Hon Lin, Shu-Hsin Liu. A comparison of 18F-FDG PET-based radiomics and deep learning in predicting regional lymph node metastasis in patients with resectable lung adenocarcinoma: a cross-scanner and temporal validation study. Nucl Med Commun. 2023;44:1094-1105 (SCIE).
03. Kun-Han Lue*, Yu-Hung Chen, Yi-Feng Wu, and Shu-Hsin Liu. Influence of the methodological aspects of the dichotomization of total metabolic tumor volume measured through baseline fluorine-18 fluorodeoxyglucose PET on survival prediction in lymphoma. Nucl Med Commun. 2023;44:74–80 (SCIE).
04. Bee-Song Chang, Tai-Chu Peng, Kun-Han Lue, Yi-Feng Wu, Chun-Hou Huang. Comprehensive assessment of the clinical risk factors of postoperative adverse events and survival in patients with non-small-cell lung cancer. In Vivo. 2023;37:1358-1364 (SCIE).
05. Yu-Hung Chen, Kun-Han Lue, Chih-Bin Lin, Kuang-Chi Chen, Sheng-Chieh Chan, Sung-Chao Chu, Bee-Song Chang, Yen-Chang Chen. Genomic and glycolytic entropy are reliable radiogenomic heterogeneity biomarkers for non-small cell lung cancer. Int J Mol Sci. 2023;16;24:3988 (SCIE).
06. Min-Feng Shih, Kun-Han Lue, Tso-Fu Wang, Sung-Chao Chu, Chun-Hou Huang. Association between the neutrophil-to-lymphocyte ratio and infection and survival in diffuse large B cell lymphoma. In Vivo. 2023;37:948-954 (SCIE).
07. Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Chih-Bin Lin. The combined tumor-nodal glycolytic entropy improves survival stratification in nonsmall cell lung cancer with locoregional disease. Nucl Med Commun. 2023, 44:100–107 (SCIE).
08. Yu-Hung Chen, Yen-Chang Chen, Kun-Han Lue*, Sung-Chao Chu*, Bee-Song Chang, Ling-Yi Wang, Ming-Hsun Li, Chih-Bin Lin. Glucose metabolic heterogeneity correlates with pathological features and improves survival stratification of resectable lung adenocarcinoma. Ann Nucl Med. 2023;37:139-150 (SCIE).
09. Kun-Han Lue, Chun-Hou Huang, Tsung-Cheng Hsieh, Shu-Hsin Liu, Yi-Feng Wu, Yu-Hung Chen. Systemic inflammation index and tumor glycolytic heterogeneity help risk stratify patients with advanced epidermal growth factor receptor-mutated lung adenocarcinoma treated with tyrosine kinase inhibitor therapy. Cancers 2022;14:309 (SCIE).
10. Kun-Han Lue, Sung-Chao Chu, Ling-Yi Wang, Yen-Chang Chen, Ming-Hsun Li, Bee-Song Chang, Sheng-Chieh Chan, Yu-Hung Chen, Chih-Bin Lin, Shu-Hsin Liu. Tumor glycolytic heterogeneity improves detection of regional nodal metastasis in patients with lung adenocarcinoma. Ann Nucl Med. 2022;36:256-266 (SCIE).
11. Chun-Hou Huang, Kun-Han Lue, Peir-Rorg Chen, Tsung-Cheng Hsieh, Yu-Fu Chou. Association between sarcopenia and immediate complications and mortality in patients with oral cavity squamous cell carcinoma undergoing surgery. Cancers 2022;14:785 (SCIE).
12. Chun-Hou Huang, Peir-Rorg Chen, Kun-Han Lue, Tsung-Cheng Hsieh, Yu-Fu Chou. Evaluation of sarcopenia, frailty, and inflammation on adverse events and survival outcomes in oatients with oral cavity squamous cell carcinoma under adjuvant chemoradiotherapy. J. Pers. Med. 2021;11:936 (SCIE).
13. Yu-Hung Chen, Sung-Chao Chu, Ling-Yi Wang, Tso-Fu Wang, Kun-Han Lue, Chih-Bin Lin, Bee-Song Chang, Dai-Wei Liu, Shu-Hsin Liu, Sheng-Chieh Chan. Prognostic value of combing primary tumor and nodal glycolytic–volumetric parameters of 18F-FDG PET in patients with non-small cell lung cancer and regional lymph node metastasis. Diagnostics 2021;11:1065 (SCIE).
14. Kun-Han Lue, Yi-Feng Wu, Hsin-Hon Lin, Tsung-Cheng Hsieh, Shu-Hsin Liu, Sheng-Chieh Chan, Yu-Hung Chen. Prognostic value of baseline radiomic features of 18F-FDG PET in patients with diffuse large B-Cell lymphoma. Diagnostics 2021;11:36 (SCIE).
15. Yu-Hung Chen, Tso-Fu Wang, Sung-Chao Chu, Chih-Bin Lin, Ling-Yi Wang, Kun-Han Lue, Shu-Hsin Liu, Sheng-Chieh Chan. Incorporating radiomic feature of pretreatment 18F-FDG PET improves survival stratification in patients with EGFR-mutated lung adenocarcinoma. PLoS ONE 2020;15:e0244502 (SCIE).
16. Yu-Hung Chen, Hwa-Tsung Chen, Ming-Che Lee, Shu-Hsin Liu, Ling-Yi Wang, Kun-Han Lue, Sheng-Chieh Chan. Preoperative F-18 fluorocholine PET/CT for the detection of hyperfunctioning parathyroid glands in patients with secondary or tertiary hyperparathyroidism: comparison with Tc-99m sestamibi scan and neck ultrasound. Ann Nucl Med. 2020;34:527-537 (SCIE).
17. Kun-Han Lue, Yi-Feng Wu, Shu-Hsin Liu, Tsung-Cheng Hsieh, Keh-Shih Chuang, Hsin-Hon Lin, Yu-Hung Chen. Intratumour heterogeneity assessed by 18F-FDG-PET predicts treatment response and survival outcomes in patients with Hodgkin lymphoma. Acad Radiol. 2020;27:e183-e192 (SCIE).
18. Chun-Hou Huang, Kun-Han Lue, Tsung-Cheng Hsieh, Shu-Hsin Liu, Tso-Fu Wang and Tai-Chu Peng. Association between sarcopenia and clinical outcomes in patients with esophageal cancer under neoadjuvant Therapy. Anticancer Res. 2020;40:1175-1181 (SCIE).
19. Kun-Han Lue, Yi-Feng Wu, Shu-Hsin Liu, Tsung-Cheng Hsieh, Keh-Shih Chuang, Hsin-Hon Lin, Yu-Hung Chen. Prognostic value of pretreatment radiomic features of F-18 FDG PET in patients with Hodgkin lymphoma. Clin Nucl Med. 2019;44:e559-e565 (SCIE).
20. Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Ling-Yi Wang, Dai-Wei Liu, Shu-Hsin Liu, Yin-Kai Chao, Sheng-Chieh Chan. Combining the radiomic features and traditional parameters of 18F-FDG PET with clinical profiles to improve prognostic stratification in patients with esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and surgery. Ann Nucl Med. 2019;33:657-670 (SCIE).
21. Yu-Hung Chen, Ching-Jung Chen, Ling-Yi Wang, Kun-Han Lue, Ching-Lin Sung, Shu-Hsin Liu. A comparison of different attenuation correction methods for calculating semiquantitative parameters of TRODAT-1 SPECT. Ann Nucl Med Mol Imaging. 2019;32;63-67.
22. Hung-Jen Hsieh, Kun-Han Lue, Hsin-Chi Tsai, Chau-Chin Lee, Shin-Yuan Chen, Pan-Fu Kao. L-3,4-Dihydroxy-6-[F-18]fluorophenylalanine positron emission tomography demonstrating dopaminergic system abnormality in the brains of obsessive–compulsive disorder patients. Psychiatry Clin Neurosci. 2014;68:292–298 (SCIE).
23. Kun-Han Lue, Hsin-Hon Lin, Chih-Hao K. Kao, Hung-Jen Hsieh, Shu-Hsin Liu, Keh-Shih Chuang. A simple algorithm for subregional striatal uptake analysis with partial volume correction in dopaminergic PET imaging. Ann Nucl Med. 2014;28:33–41 (SCIE).
24. I-Cheng Chang, Kun-Han Lue, Hung-Jen Hsieh, Shu-Hsin Liu, Chih-Hao K. Kao. Automated striatal uptake analysis of 18F-FDOPA PET images applied to Parkinson disease patients. Ann Nucl Med. 2011; 25:796–803 (SCIE).
25. Hung-Jen Hsieh, Kun-Han Lue, Chih-Hao K. Kao, Yung-Hsiang Hsu, Ming-Chien Liu, and Pan-Fu Kao. Portosystemic collateral circulation: Demonstrated by Tc-99m-RBC SPECT/CT. Clin Nucl Med. 2009; 34:958-959 (SCIE).
26. Hung-Jen Hsieh, Kun-Han Lue, Bee-Song Chang, Chih-Hao K. Kao, Shu-Hsin Liu and Pan-Fu Kao. Port-A catheter fracture: a potential lethal iatrogenic complication identified in PET-CT. Ann Nucl Med Sci. 2009;22:47-51.
27. Hung-Jen Hsieh, Kun-Han Lue, The cephalad malposition of kidney as thoracic abnormality in Tc-99m MDP bone scintigraphy. Tzu Chi Med J. 2008;20:314-317 (ESCI).
 
研討會論文
01. Kun-Han Lue, Kuo-Yi Kan, Yu-Hung Chen, Shu-Shin Liu, I-Ling Shih, and Hsin-Hon Lin. Clinical evaluation of 18F-FDG PET radiomics stability to respiratory motion using a data-driven respiratory gating algorithm. 2023 Annual Congress of the European Association of Nuclear Medicine (EANM), Vienna, Austria.
02. Kun-Han Lue, Yu-Hung Chen, Li Min Yong, Xin Yi Wong, Shu-Shin Liu, and Hsin-Hon Lin. Convolutional neural network for prediction of early disease progression in patients with advanced epidermal growth factor receptor-mutated lung adenocarcinoma receiving tyrosine kinase inhibitor therapy based on 18F-FDG PET images. 2023 Annual Congress of the European Association of Nuclear Medicine (EANM), Vienna, Austria.
03. Li Min Yong, Xin Yi Wong, Yu-Hung Chen, Shu-Shin Liu, Hsin-Hon Lin, and Kun-Han Lue. The effect of feature selection methods on prognostic analysis of 18F-FDG PET radiomics in lymphoma. 2023 Annual Congress of the European Association of Nuclear Medicine (EANM), Vienna, Austria.
04. Xin Yi Wong, Li Min Yong, Yu-Hung Chen, Shu-Shin Liu, and Kun-Han Lue. Using different dichotomisation methods for lesion dissemination to predict survival outcomes in lymphoma patients. 2023 Annual Congress of the European Association of Nuclear Medicine (EANM), Vienna, Austria.
05. Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Kuang-Chi Chen, and Shu-Hsin Liu. Using Deep Learning Model to Categorize Tumor Mutation Burden in Non-Small Cell Lung Cancer. Taiwan Society of Nuclear Medicine. 2023 Annual Meeting, Taichung, Taiwan.
06. Ho-Yan Rong, Yu-Hung Chen, Kun-Han Lue, and Shu-Hsin Liu. Cross-Scanner Validation of the Prognostic Value of Glycolytic Entropy in Lung Cancer. Taiwan Society of Nuclear Medicine. 2023 Annual Meeting, Taichung, Taiwan.
07. Ho Tim Shek, Kun-Han Lue, Chao-Yueh Yu, Chih-Chieh Chiang, Tzu-Pei Su, and Hsin-Hon Lin. Deep learning-based automatic segmentation for myocardial perfusion SPECT imaging using V-Net. 2023 International Symposium of Medical Imaging and Radiological Sciences, Kaohsiung, Taiwan.
08. Yu-Hung Chen, Kun-Han Lue. Evaluation of radiomic features reliability in lower resolution images using reduced-matrix-size 18F-FDG PET. Taiwan Society of Nuclear Medicine. 2022 Annual Meeting, Taipei, Taiwan. 
09. Yu-Hung Chen, Kuang-Chi Chen, Kun-Han Lue, Sung-Chao Chu. Correlation of 18F-FDG PET features with glucose metabolic signature gene mutation in non-small cell lung cancer. Taiwan Society of Nuclear Medicine. 2022 Annual Meeting, Taipei, Taiwan.
10. Chung-Ying Huang, Yu-Hung Chen, Kun-Han Lue, Yi-Feng Wu, Sung-Chao Chu. The combination of systemic inflammation marker and tumor glycolytic-volumetric product as prognostic models in NSCLC patients with regional lymph node metastasis. Taiwan Society of Nuclear Medicine. 2022 Annual Meeting, Taipei, Taiwan.
11. Chao-Yueh Yu, Kun-Han Lue, Ho-Ting Yang, Tzu-Pei Su, Hsin-Hon Lin. Attenuation correction for myocardial perfusion SPECT using multi-stream 3D residual network. 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference. Yokohama, Japan.
12. Yu-Hung Chen, Yen-Chang Chen, Ming-Hsun Li, Sung-Chao Chu, Kun-Han Lue. The glycolytic features extracted from 18F-FDG PET are correlated with morphological features of surgical pathology in lung adenocarcinoma. Taiwan Society of Nuclear Medicine. 2021 Annual Meeting, Taichung, Taiwan.
13. Yu-Hung Chen, Sung-Chao Chu, Kun-Han Lue, Sheng-Chieh Chan, Shu-Hsin Liu. The prognostic value of 18F-FDG PET in patients with advanced small cell lung cancer. Taiwan Society of Nuclear Medicine. 2021 Annual Meeting, Taichung, Taiwan.
14. Ching-Lin Sung, Sze Ian Tan, Shu-Hsin Liu, Sheng-Chieh Chan, Kun-Han Lue. Evaluating the image quality of digital PET/CT: using different scanning time and reconstruction method. Taiwan Society of Nuclear Medicine. 2021 Annual Meeting, Taichung, Taiwan.
15. Yu-Hung Chen, Ming-Hsun Li, Sung-Chao Chu, Kun-Han Lue, Shu-Hsin Liu, Sheng-Chieh Chan. Tumor glycolytic heterogeneity measured from 18F-FDG PET is associated with PD-L1 expression in esophageal squamous cell carcinoma. Taiwan Society of Nuclear Medicine. 2020 Annual Meeting, Taipei, Taiwan.
16. Yu-Hung Chen, Kun-Han Lue, Shu-Hsin Liu, Sheng-Chieh Chan. Comparison of the 18F-FDG PET derived radiomic features between different softwares. Taiwan Society of Nuclear Medicine. 2020 Annual Meeting, Taipei, Taiwan.
17. Ching-Lin Sung, Yu-Hung Chen, Kun-Han Lue, Shu-Hsin Liu, Sung-Chao Chu, Ching-Chun Ho. Identifying potential predictor for the interference of Tc-99m bone radiopharmaceuticals in dual-energy X-ray absorptiometry using lasso and logistic regression statistics. Taiwan Society of Nuclear Medicine. 2020 Annual Meeting, Taipei, Taiwan.
18. Kun-Han Lue, Yu-Hung Chen, Hsin-Hon Lin, Yi-Feng Wu, Shu-Hsin Liu, Sheng-Chieh Chan. Using different methods for metabolic tumour volume dichotomization to predict survival of patients with Hodgkin lymphoma. Australian and New Zealand Society of Nuclear Medicine. 2020 Annual Meeting, Sydney, Australia.
19. Kun-Han Lue, Hsin-Hon Lin, Yu-Hung Chen, Shu-Hsin Liu, Chih-Hao K. Kao. Keh-Shih Chuang. Relationship between prostate‐specific antigen kinetics and radiomic features of F‐18 fluorocholine PET in patients with prostate Cancer. Society of Nuclear Medicine and Molecular Imaging. 2019 Annual Meeting (SNMMI)., Anaheim, USA.
20. Kun-Han Lue, Hsin-Hon Lin, Yu-Hung Chen, Shu-Hsin Liu, Keh-Shih Chuang. Embedding partial volume correction in atlas‐based image analysis for substriatal uptake in dopaminergic PET imaging. Society of Nuclear Medicine and Molecular Imaging (SNMMI). 2019 Annual Meeting, Anaheim, USA.
21. Hsin-Hon Lin, Chih-Chieh Chiang, Kun-Han Lue, Yu-Ching. Ni, Keh-Shih Chuang. Improvement of the distortion effect in dual head PET scanner for breast imaging using an add-on Compton camera. 2016 Annual Congress of the European Association of Nuclear Medicine (EANM), Barcelona, Spain.
22. Kun-Han Lue, Hsin-Hon Lin, Chang-Shiun Lin, Chih-Chieh, Keh-Shih Chuang. Chuang. Effects of random, scatter, attenuation, and partial volume corrections on the quantification of dopaminergic PET imaging. 2016 Annual Congress of the European Association of Nuclear Medicine (EANM), Barcelona, Spain.
23. Keh-Shih Chuang, Kun-Han Lue, Hsin-Hon Lin, Hsin-ChaoWang, Yu-Ching Ni, Meei-Ling Jan. Improved attenuation correction method for SPECT by iterative filtered backprojection reconstruction. 2014 Annual Congress of the European Association of Nuclear Medicine (EANM), Gothenburg, Sweden.
24. Keh-Shih Chuang, Chih-Hung Chien, Hsin-Hon Lin, Kun-Han Lue, Chih-Chieh Chiang, Meei-Ling Jan. Dual Isotopes Simultaneous Acquisition of Tc-99m and F-18 using PET with beam stopper device. 2014 Annual Congress of the European Association of Nuclear Medicine (EANM), Gothenburg, Sweden.
25. Hsin-Chau Wang, Kun-Han Lue, Hsin-Hon Lin, Keh-Shih Chuang. Improvement of attenuation correction for single photon emission computed tomography. 2014 International Symposium of Medical Imaging and Radiological Sciences, Taichung, Taiwan.
26. Shih-Chi Lin, Yi-Fang Wang, Kun-Han Lue, Hsin-Hon Lin, Keh-Shih Chuang. An Improved technique for scatter correction in PET. 2014 American Association of Physicists in Medicine (AAPM) Annual Meeting, Austin, USA.
27. Yi-Fang Wang, Shih-Chi Lin, Chia-Hung Lu, Kun-Han Lue, Lu-Han Lai, Keh-Shih Chuang. A novel application of SIFT technique to microcalcification detection. 2014 American Association of Physicists in Medicine (AAPM) Annual Meeting, Austin, USA.
28. Kun-Han Lue, Hsin-Hon Lin, Chih-Hao K. Kao, Hung-Jen Hsieh, Shu-Hsin Liu, Keh-Shih Chuang. Partial volume correction for subregional analysis of striatal uptake in Dopaminergic PET imaging. 2013 Annual Congress of the European Association of Nuclear Medicine (EANM), Lyon, France.
29. Hsin-Hon Lin, Keh-Shih Chuang, Chih-Hung Chien, Kun-Han Lue, Chih-Chieh Chiang, Meei-Ling Jan. Simultaneous SPECT and PET dual-tracer imaging using beam stopper device. 2013 Annual Congress of the European Association of Nuclear Medicine (EANM), Lyon, France.
30. Kun-Han Lue, I-Cheng Chang, Hung-Jen Hsieh, Shu-Hsin Liu, and Chih-Hao K. Kao, An objective method for manual striatal uptake analysis applied to 18F-FDOPA PET Images of Parkinson disease patients. 2010 Taiwan International Symposium on Radiopharmaceutical Development and Application, Hualien, Taiwan.
31. Hung-Jen Hsieh, Shin-Chi Tsai, Shin-Yuan Chen, Kun-Han Lue, Chih-Hao K. Kao, The neuronal circuitry of obsessive-compulsive disorder and neuromodulatory mechanism of deep brain stimulation: Explored by F-18 FDG PET. Society of Nuclear Medicine. 2010 Annual Meeting, Utah, USA.