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陳立仁

陳立仁照片
 
姓名 陳立仁
職稱
 助理教授兼自然學科組長
學歷
成功大學基礎醫學研究所 博士
中國醫藥大學醫學研究所 碩士
輔仁大學護理學系 學士
專長
 糖尿病心肌病變、糖尿病腎病變、神經保護因子、抗老化因子、心血管反射生理病理、中草藥治療應用
E-Mail
sc75@tcust.edu.tw
聯絡電話

(03)8572158 ext 2365 
Fax:(03)8561396
 
教學科目
 生理學、病理學、生理學實驗
 
期刊論文(Journal paper)：
1. Cerebral klotho protein as a humoral factor for maintenance of baroreflex. Chen LJ, Cheng MF, Ku PM, Cheng JT. Horm Metab Res. 2014.
2. Decrease of PPARd in type-1-like diabetic rat for higher mortality after spinal cord injury. Tsai CC, Lee KS, Chen SH, Chen LJ, Liu KF, and Cheng JT. PPAR Res. 2014; 2014: 456386. Epub 2014 Apr 10.
3. Changes of urinary bladder contractility in high-fat diet-fed mice: The role of tumor necrosis factor-α. Fan WC, Chen LJ, Cheng JT and Tong YT. Int J Urol. 2014 Mar 24. [Epub ahead of print]
4. Characterization of imidazoline receptors in blood vessels for development of antihypertensive agents. Chen MF, Tsai JT, Chen LJ, Wu TP, Yang JJ, Yin LT, Yang YL, Chiang TA, Lu HL, and Wu MC. Biomed Res Int. 2014; 2014: 182846. Epub 2014 Apr 3.
5. Antihypertensive action of allantoin in animals. Chen MF, Tsai JT, Chen LJ, Wu TP, Yang JJ, Yin LT, Yang YL, Chiang TA, Lu HL, and Wu MC. Biomed Res Int. 2014; 2014: 690135. Epub 2014 Mar 12.
6. Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats. Tsai CC, Chan P, Chen LJ, Chang CK, Liu ZM, and Lin JW. Biomed Res Int. 2014; 2014: 484161. Epub 2014 Mar 17.
7. Characterization of musclin as new target for treatment of hypertension. Lin JW, Tsai CC, Chen LJ, Niu HS, Chang CK, and Niu CS. Biomed Res Int. 2013; 2013: 354348. Epub 2014 Mar 9.
8. Ginseng is useful to enhance cardiac contractility in animals. Lin JW, Cherng YG, Chen LJ, Niu HS, Chang CK, and Niu CS. Biomed Res Int. 2014; 2014: 723084. Epub 2014 Feb 4.
9. Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats. Chen LJ, Cheng MF, Ku PM, Lin JW. Biomed Res Int. 2014; 2014: 309151. Epub 2014 Feb 13.
10. Antihyperglycemic action of rhodiola-aqeous extract in type1-like diabetic rats. Niu CS, Chen LJ and Niu HS. BMC Complement Altern Med. 2014 Jan 13.
11. Role of peroxisome proliferator-activated receptors d (PPARd) in rats showing endotoxemic heart failure. Chang PC, Li-Jen Chen, Cheng JT. J. Appl. Biomed. 2013 May.
12. Rosiglitazone is Effective to Improve Renal Damage in Type-1-like Diabetic Rats. Huang KC, Cherng YG, Chen LJ, Hsu CT, Cheng JT. Horm Metab Res. 2013 Oct 17.
13. Dual effects of silymarin on nasopharyngeal carcinoma cells (NPC-TW01). Su CH, Chen LJ, Liao JF, Cheng JT. Forsch Komplementmed. 2013; 20(4):261-6. Epub 2013 Aug 15.
14. Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. Su CH, Chen LJ, Liao JF, Cheng JT. J Med Food. 2013 Sep;16(9):778-84. Epub 2013 Aug 3.
15. Decrease of FGF Receptor (FGFR) and Interstitial Fibrosis in the Kidney of Streptozotocin-induced Diabetic Rats. Cheng MF, Chen LJ, Wang MC, Hsu CT, Cheng JT. Horm Metab Res. 2013 Jul 4
16.Activation of Receptors δ (PPARδ) by Agonist (GW0742) may Enhance Lipid Metabolism in Heart both In Vivo and In Vitro. Kuo SC, Ku PM, Chen LJ, Niu HS, Cheng JT. Horm Metab Res. 2013 Jun 26.
17.Cardiac peroxisome proliferator-activated receptor δ (PPARδ) as a new target for increased contractility without altering heart rate. Chen ZC, Lee KS, Chen LJ, Wang LY, Niu HS, Cheng JT. PLoS One. 2013 May 28.
18. Increase of PPARδ by dopamine mediated via DA-1 receptor-linked phospholipase C pathway in neonatal rat cardiomyocytes. Lo SH, Lee KS, Chen LJ, Cheng JT, Chen CH. Auton Neurosci. 2013 May 20.
19. Doxorubicin-Induced Cardiac Toxicity Is Mediated by Lowering of Peroxisome Proliferator-Activated Receptor δ Expression in Rats. Chen ZC, Chen LJ, Cheng JT. PPAR Res. Epub 2013 Feb 28.
20. Characterization of the specificity of imidazoline I-1 receptor antibody for subtype of imidazoline receptors in vitro. Wang LY, Ku PM, Chen SH, Chen LJ, Yu YM, Cheng JT. Horm Metab Res. 2013 Jul; 45(7):485-9.
21. Increase of peroxisome proliferator-activated receptor δ (PPARδ) by digoxin to improve lipid metabolism in the heart of diabetic rats. Chen ZC, Yu BC, Chen LJ, Cheng JT. Horm Metab Res. 2013 May; 45(5):364-71.
22. Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats. Cheng YZ, Chen LJ, Lee WJ, Chen MF, Jung Lin H, Cheng JT. J Ethnopharmacol. 2012 Nov 21; 144(2):234-9.
23. Role of TNF-α in renal damage in mice showing hepatic steatosis induced by high fat diet. Lai YH, Chen LJ, Cheng JT. Horm Metab Res. 2013 Jan; 45(1):38-42.
24. Activation of β-adrenoceptors by dobutamine may induce a higher expression of peroxisome proliferator-activated receptors δ (PPARδ) in neonatal rat cardiomyocytes. Chou MT, Lo SH, Cheng KC, Li YX, Chen LJ, Cheng JT. ScientificWorldJournal. Epub 2012 May 15.
25. Increase in cardiac M2-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats. Mar GY, Ku PM, Chen LJ, Cheng KC, Li YX, Cheng JT. Int J Cardiol. 2013 Jul 31; 167(2):436-41.
26. Plasma glucose-lowering action of allantoin is induced by activation of imidazoline I-2 receptors in streptozotocin-induced diabetic rats. Lin KC, Yeh LR, Chen LJ, Wen YJ, Cheng KC, Cheng JT. Horm Metab Res. 2012 Jan;44(1):41-6.
27. Silymarin inhibits cervical cancer cell through an increase of phosphatase and tensin homolog. Yu HC, Chen LJ, Cheng KC, Li YX, Yeh CH, Cheng JT. Phytother Res. 2012 May; 26(5):709-15.
28. Increase of ATP-sensitive potassium KATP channels in the heart of type-1 diabetic rats. Chen ZC, Cheng YZ, Chen LJ, Cheng KC, Li Y, Cheng JT. Cardiovasc Diabetol. 2012 Jan 18
29. The acid sphingomyelinase inhibitors block interferon-α-induced serotonin uptake via a COX-2/Akt/ERK/STAT-dependent pathway in T cells. Su HC, Ma CT, Lin CF, Wu HT, Chuang YH, Chen LJ, Tsao CW. Int Immunopharmacol. 2011 Nov; 11(11):1823-31.
30. Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPARα in liver of mice fed high-fat diet. Niu CS, Chen CT, Chen LJ, Cheng KC, Yeh CH and Cheng JT. Horm Metab Res. 2011 Aug;43(9):625-30.
31. Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Ku PM, Chen LJ, Liang JR, Cheng KC, Li YX, Cheng JT. Cardiovasc Diabetol. 2011 Jun 24; 10:57.
32. Changes of CCAAT enhancer-binding proteins (CEBPs) in the lung of streptozotocin-induced diabetic rats. Fong Y, Shen KH, Chen LJ, Cheng JT. Horm Metab Res. 2011 Apr;43(4):261-7.
33. Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line. Chen ZC, Yu BC, Chen LJ, Cheng KC, Lin HJ, Cheng JT. Br J Pharmacol. 2011 May; 163(2):390-8.
34. Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats. Cheng MF, Chen LJ, Cheng JT. J Biomed Biotechnol. Epub 2010 Jun 27.
35. The decreased expression of peroxisome proliferator-activated receptors delta (PPARdelta) is reversed by digoxin in the heart of diabetic rats. Fan SC, Yu BC, Chen ZC, Chen LJ, Chung HH, Cheng JT. Horm Metab Res. 2010 Aug;42(9):637-42.
36. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. Cheng TC, Lin CS, Hsu CC, Chen LJ, Cheng KC, Cheng JT. Neurosci Lett. 2009 Nov 20; 465(3):238-41.of the Rheumatic Diseases. 2007; 66:1264-1266.g KC, Cheng JT. Neurosci Lett. 2009 Nov 20; 465(3):238-41.of the Rheumatic Diseases. 2007; 66:1264-1266.
 
專業服務:
 
國際期刊Invited reviewer:
Chinese journal of physiology
Clinical and Experimental Pharmacology and Physiology
Biomedical research international
International Invention Journal of Biochemistry and Bioinformatics
Journal of Cardiology and Therapy
 
國際期刊member of editorial board:
Journal of Cardiology and Therapy
醫療財團法人奇美醫院胸腔內科 演講：研究方法與實驗設計
國立成功大學附設醫院內科部 演講：臨床研究設計
臺南市樂齡學習中心 講座：漫談代謝症候群---用藥與保健
臺南市樂齡學習中心 講座：痛風---保健與治療
私立長榮大學呼吸照護學系 講座: 進階呼吸生理學
 
專書：
博士論文「腦內Klotho在神經保護與維持心血管感壓反射中所扮演的角色」 碩士論文「運動訓練在Zucker肥胖鼠血管保護效果中所扮演的角色」