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陽明大學生理學研究所博士 (1999-2004)


  1. 動物實驗 (行為分析、神經核定位、神經路徑追蹤劑注射、神經化學物質分析、組織化學分析、神經藥理實驗、基因表現偵測、糖尿病動物模式)
  2. 細胞培養實驗





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  1. Shu-ChuanYang co, Chien-Lin Chen co, Chih-Hsun Yi , Tso-Tsai Liu, *Kun-Ruey Shieh: Changes in Gene Expression Patterns of Circadian-Clock, Transient Receptor Potential Vanilloid-1 and Nerve Growth Factor in Inflamed Human Esophagus. Sci Rep. 2015 Sep 4;5:13602. (co These Authors contributed equally to this work)(2014 IF: 5.578, MULTIDISCIPLINARY SCIENCES: 5/57=8.7%)
  2. co Tseng HL, co Yang SC, Yang SH, *Shieh KR: Hepatic circadian-clock system altered by insulin resistance, diabetes and insulin sensitizer in mice. PLoS One. 2015 Mar 23;10(3):e0120380. (Tseng HL and Yang SC contributed equally to this work as the co-first author)(2013 IF: 3.534, MULTIDISCIPLINARY SCIENCES: 8/55=14.5%)
  3. KR. Shieh, SC. Yang, HL. Tseng, CH. Yi, TT. Liu and *CL. Chen: Evidence for Up-Regulation of Purinergic Receptor Genes Associating with TRPV1 Receptors and Neurotrophic Factors in the Inflamed Human Esophagus. Current Molecular Medicine 2014, 14: 1-10 (2013 IF:3.612, MEDICINE, RESEARCH & EXPERIMENTAL:31/124=25%)
  4. Yang SC, Tseng HL, *Shieh KR: Circadian-clock system in mouse liver affected by the insulin resistance. Chronobiology International. 2013, 30: 796–810 (2013 IF: 2.487, BIOLOGY: 19/85=22.3%)
  5. co Hsieh MC, co Yang SC, Tseng HL, Hwang LL, Chen CT, *Shieh KR: Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long term, high-fat diet-treated mice. International Journal of Obesity. 2010, Feb;34(2):227-39.  (Hsieh MC and Yang SC contributed equally to this work as the co-first author) (2013 IF: 5.386, NUTRITION & DIETETICS: 6/79 = 7.5%)
  6. Shieh KR, *Yang SC: Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats. Neuroscience. 2008, 154:1589-1597. (2013 IF: 3.380, NEUROSCIENCES: 94/244 = 38.5%)
  7. Shieh KR, Lee HJ, *Yang SC: Different patterns of food consumption and locomotor activity between Taiwanese native rodent, formosan wood mouse (Apodemus semotus), and common laboratory mouse, C57BL/6 (Mus musculus). Chinese Journal of Physiology. 2008, 51: 129-135. (2013 IF: 1.275, PHYSIOLOGY: 65/81 = 80.2%)
  8. Yang SC, *Shieh KR: Gonadal Hormones-mediated Effects on the Stimulation of Dopamine Turnover Mesolimbic and Nigrostriatal Systems by Cocaine- and Amphetamine-regulated Transcript (CART) Peptide in Male Rats. Neuropharmacology. 2007, 53: 801-809. (2013 IF: 4.819, PHARMACOLOGY & PHARMACY: 23/256 = 8.9%)
  9. Yang SC, Shieh KR, *Li HY: Cocaine- and amphetamine-regulated transcript (CART) peptide in the nucleus accumbens participates in the regulation of feeding behavior in rats. Neuroscience. 2005, 133: 841-851. (2013 IF: 3.327, NEUROSCIENCES: 104/252 = 41.2%)
  10. Yang SC, *Shieh KR: Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript. Journal of Neurochemistry. 2005, 92: 637-646. (2013 IF:4.244, NEUROSCIENCES: 63/252 = 25%)
  11. *Shieh KR, Yang SC, Lu XY, Akil H, Watson SJ: Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. Journal of Biomedical Science. 2005, 12: 209-217. (2013 IF: 2.736, MEDICINE, RESEARCH & EXPERIMENTAL:49/124 = 39.5%)
  12. Yang SC, *Shieh KR: Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of tuberoinfundibular dopaminergic neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin. Neuropharmacology. 2004, 47: 1070-1080. (2013 IF: 4.819, PHARMACOLOGY & PHARMACY: 23/256 = 8.9%)
  13. Yang SC, Pan JT and *Li HY: CART peptide increases the mesolimbic dopaminergic neuronal activity: a microdialysis study. European Journal of Pharmacology 2004, 494: 179-182. (2013 IF:2.684, PHARMACOLOGY & PHARMACY: 98/256 = 38.2%)
  14. Yang SC and *Pan JT: Differential effects of colchicine on central dopaminergic neuronal activity and prolactin secretion in estrogen-primed ovariectomized rats. Chinese Journal of Physiology. 2003, 46:15-18. (2013 IF: 1.275, PHYSIOLOGY: 65/81 = 80.2%)
  15. Yuan ZF, Yang SC and *Pan JT: Effects of prolactin-releasing peptide on tuberoinfundibular dopaminergic neuronal activity and prolactin secretion in estrogen-treated female rats. Journal of Biomedical Science. 2002, 9:112-118. (2013 IF: 2.736, MEDICINE, RESEARCH & EXPERIMENTAL:49/124 = 39.5%)



  1. 2005/8/1-2006/7/31 古柯鹼與安非他命調節胜肽對中腦多巴胺神經系統的影響 (國科會專題研究計畫 NSC 94-2320-B-277-001)
  2. 2006/8/1-2008/7/31 性腺激素影響古柯鹼及安非他命調節轉錄胜肽對中腦多巴胺神經系統的作用機轉,以及古柯鹼及安非他命調節轉錄胜肽與類鴉片和迦瑪-胺基丁酸神經系統的交互作用 ( 國科會專題研究計畫NSC 95-2320-B-277-001-MY2)
  3. 2008/8/1-2011/7/31 古柯鹼及安非他命調節轉錄胜肽在性腺激素所調節之神經保護機制的角色  (國科會專題研究計畫 NSC 97-2314-B-277-001-MY3)
  4. 2014/8/1-2015/7/31 探討BDNFPGC-1 alpha在過動症小鼠模式中的角色 (科技部專題研究計畫 MOST 103-2410-H-277 -001)