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Shu-Chuan Yang,Ph.D.


Associate Professor



National Yang-Ming University                                                  Taipei, Taiwan

PH.D., Institute of Physiology, National Yang-Ming (1999-2004)

M.S., Institute of Physiology, National Yang-Ming (1997-1999)


1.     The mechanisms of CART peptide psychostimulant-like effect. (2004~2008)

(1)   Effects of cocaine- and amphetamine-regulated transcript peptide on regulation of midbrain dopaminergic systems (NSC94-2320-B-277-001, 2005/08/01-2006/07/31)

(2)   Effects and mechanisms of gonadal hormones on the actions of cocaine- and amphetamine-regulated (CART) peptide to midbrain dopaminergic systems, and the interactions of CART peptide with opioidergic and GABAergic systems (NSC95-2320-B-277-001-MY2, 2006/08/01-2008/07/31)

2.     The mechanisms of CART peptid involve neuronal protection. (2008~2011)

(1)  The role of CART peptide in gonadal hormones-mediated neuroprotection (NSC97-2314-B-277-001-MY3, 2008/08/01-2011/07/31)

3.     Roles of BDNF and PGC-1 alpha in the mouse model of ADHD (MOST 103-2410-H-277-001 2014/08/01-2015/07/31)

4.     The mechanisms of radiation-induced cognitive impairment


7th International Brain Research Organization (IBRO) World Congress of Neuroscience travel award (2007)

第89回日本生理學大會優選論文獎 (2012)  89th Annual Meeting of the Physiological Society of Japan


1.     Shu-ChuanYang co, Chien-Lin Chen co, Chih-HsunYi , Tso-Tsai Liu, *Kun-Ruey Shieh: Changes in Gene Expression Patterns of Circadian-Clock, Transient Receptor Potential Vanilloid-1 and Nerve Growth Factor in Inflamed Human Esophagus. Sci Rep. 2015 Sep 4;5:13602. (co These Authors contributed equally to this work)(2014 IF: 5.578, MULTIDISCIPLINARY SCIENCES: 5/57=8.7%)

2.     co Tseng HLco Yang SCYang SH, *Shieh KR: Hepatic circadian-clock system altered by insulin resistance, diabetes and insulin sensitizer in mice. PLoS One. 2015 Mar 23;10(3):e0120380. (Tseng HL and Yang SC contributed equally to this work as the co-first author)(2013 IF: 3.534, MULTIDISCIPLINARY SCIENCES: 8/55=14.5%)

3.     KR. Shieh, SC. Yang, HL. Tseng, CH. Yi, TT. Liu and *CL. Chen: Evidence for Up-Regulation of Purinergic Receptor Genes Associating with TRPV1 Receptors and Neurotrophic Factors in the Inflamed Human Esophagus. Current Molecular Medicine 2014, 14: 1-10 (2013 IF:3.612, MEDICINE, RESEARCH & EXPERIMENTAL:31/124=25%)

4.     Yang SC, Tseng HL, *Shieh KR: Circadian-clock system in mouse liver affected by the insulin resistance. Chronobiology International. 2013, 30: 796–810 (2013 IF: 2.487, BIOLOGY: 19/85=22.3%)

5.     co Hsieh MC, co Yang SC, Tseng HL, Hwang LL, Chen CT, *Shieh KR: Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long term, high-fat diet-treated mice. International Journal of Obesity. 2010, Feb;34(2):227-39.  (Hsieh MC and Yang SC contributed equally to this work as the co-first author) (2013 IF: 5.386, NUTRITION & DIETETICS: 6/79 = 7.5%)

6.     Shieh KR, *Yang SC: Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats. Neuroscience. 2008, 154:1589-1597. (2011 IF: 3.380, NEUROSCIENCES: 94/244 = 38.5%)

7.     Shieh KR, Lee HJ, *Yang SC: Different patterns of food consumption and locomotor activity between Taiwanese native rodent, formosan wood mouse (Apodemus semotus), and common laboratory mouse, C57BL/6 (Mus musculus). Chinese Journal of Physiology. 2008, 51: 129-135. (2013 IF: 1.275, PHYSIOLOGY: 65/81 = 80.2%)

8.     Yang SC, *Shieh KR: Gonadal Hormones-mediated Effects on the Stimulation of Dopamine Turnover Mesolimbic and Nigrostriatal Systems by Cocaine- and Amphetamine-regulated Transcript (CART) Peptide in Male Rats. Neuropharmacology. 2007, 53: 801-809. (2013 IF: 4.819, PHARMACOLOGY & PHARMACY: 23/256 = 8.9%)

9.     Yang SC, Shieh KR, *Li HY: Cocaine- and amphetamine-regulated transcript (CART) peptide in the nucleus accumbens participates in the regulation of feeding behavior in rats. Neuroscience. 2005, 133: 841-851. (2013 IF: 3.327, NEUROSCIENCES: 104/252 = 41.2%)

10.  Yang SC, *Shieh KR: Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript. Journal of Neurochemistry. 2005, 92: 637-646. (2013 IF:4.244, NEUROSCIENCES: 63/252 = 25%)

11.  *Shieh KR, Yang SC, Lu XY, Akil H, Watson SJ: Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. Journal of Biomedical Science. 2005, 12: 209-217. (2013 IF: 2.736, MEDICINE, RESEARCH & EXPERIMENTAL:49/124 = 39.5%)

12.  Yang SC, *Shieh KR: Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of tuberoinfundibular dopaminergic neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin. Neuropharmacology. 2004, 47: 1070-1080. (2013 IF: 4.819, PHARMACOLOGY & PHARMACY: 23/256 = 8.9%)

13.  Yang SC, Pan JT and *Li HY: CART peptide increases the mesolimbic dopaminergic neuronal activity: a microdialysis study. European Journal of Pharmacology 2004, 494: 179-182. (2013 IF:2.684, PHARMACOLOGY & PHARMACY: 98/256 = 38.2%)

14.  Yang SC and *Pan JT: Differential effects of colchicine on central dopaminergic neuronal activity and prolactin secretion in estrogen-primed ovariectomized rats. Chinese Journal of Physiology. 2003, 46:15-18. (2013 IF: 1.275, PHYSIOLOGY: 65/81 = 80.2%)

15.  Yuan ZF, Yang SC and *Pan JT: Effects of prolactin-releasing peptide on tuberoinfundibular dopaminergic neuronal activity and prolactin secretion in estrogen-treated female rats. Journal of Biomedical Science. 2002, 9:112-118. (2013 IF: 2.736, MEDICINE, RESEARCH & EXPERIMENTAL:49/124 = 39.5%)